He also directed the 2011 short film Portal: No Escape, an episode of Black Mirror entitled "Playtest", and various television commercials and public service announcements.

In April 2008, he joined Tight Films,[4] for which he collaborated with Matt Wolf on an alternate reality game for Hellboy II: The Golden Army.

In March 2011, Trachtenberg released a short film for BlackBoxTV titled More Than You Can Chew, starring J. Kristopher, Skye Marshall and Ian Hamrick.

[6] On October 13, 2011, /Film announced that Trachtenberg would be directing a science fiction action heist film for Universal Pictures with writer Chris Morgan.

[9] On April 3, 2014, Ain't It Cool News announced that Trachtenberg would direct a film for Bad Robot titled Valencia, which was later revealed to be a code name for 10 Cloverfield Lane.

"[12] On April 30, 2018, it was announced that Dan Trachtenberg would direct the first episode of the Amazon series The Boys, replacing Seth Rogen and Evan Goldberg, who dropped out due to scheduling conflicts.

[15] On November 20, 2020, it was announced that Trachtenberg had been engaged by 20th Century Studios to direct the fifth installment in the Predator film series, titled Prey.