[7] At age 17, Van de Donk first played as a professional football for Dutch Eredivisie club, Willem II.

With Eindhoven, Van de Donk reached the final of the KNVB Cup of 2014, where she eventually earned a runners-up medal.

[2] During a match on 11 October, Van de Donk scored a brace —the team's only goals — in a 4–2 loss to KIF Örebro.

Arsenal were eventually crowned champions, beating Chelsea 1–0 at the Wembley Stadium to earn their fourteenth FA Cup title.

[21] On 7 October 2016, Van de Donk signed a new contract with Arsenal[22] and was a starting midfielder in 14 of the 15 games she played.

Van de Donk scored three goals helping lift Arsenal to a third place finish with a 10–4–2 record.

[28] Marking her fifth year with the club, Van de Donk signed a new long-term contract with Arsenal in March 2019.

[29] Of the signing, Arsenal manager Joe Montemurro said, "She brings a world class attitude and quality that are vital to our team.

[34] At the age of 19, Van de Donk made her debut for the Netherlands national team in a match against Mexico on 15 December 2010 at the 2010 City of São Paulo Tournament.

[35] In June 2013, Dutch national team coach Roger Reijners selected Van de Donk for the Netherlands squad for UEFA Euro 2013 in Sweden.

Van de Donk competed at the 2015 FIFA World Cup in Canada under the direction of Reijners.

[38] On 14 June 2017, Van de Donk was selected as part of the Dutch squad for UEFA Euro 2017 on home soil.

Van de Donk also played in the final against Denmark, where her creative presence helped the Netherlands come away with a victory.

[41] Van de Donk was selected to the final squad for the 2019 FIFA World Cup in France.

[7] In the Euro 2022, Van de Donk scored the winning goal in the 3–2 match against Portugal, helping her team advance to the knockout stage.

[51] In the group stage game against the United States, Van de Donk hit her head and received treatment for several minutes.