[4] He eventually made it into his local club Xerez CD and, after one season there, first showed his eye for goal at Segunda División B side Dos Hermanas CF, loaned immediately after RCD Mallorca bought him.

[5] Subsequently, he joined Ciudad de Murcia of the Segunda División, where his career saw a turning point with two consecutive top-five finishes in the top scorers' list (runner-up in the 2004–05 season).

[5] On 10 May 2007, he was one of three players on target in a 4–0 home defeat of FC Barcelona for the semi-finals of the Copa del Rey, which meant qualification for the decisive match for the first time ever after a 6–5 aggregate win.

[7] After four years, Güiza returned to Mallorca in a €5 million move, brokered by his wife and agent Nuria Bermúdez, experiencing a breakthrough season.

Prior to the beginning of 2009–10 he put three past Budapest Honvéd FC in the third qualifying round of the UEFA Europa League, in a 5–1 home win (6–2 on aggregate),[12] netting his first in the domestic competition in matchday one against Denizlispor, in the first minute of the game.

[17] His move, along with the acquisition of former S.S. Lazio winger Simone Del Nero and seven Malaysian internationals, was part of the club's major restructuring plans upon the appointment of Tunku Ismail Idris, the Crown Prince of Johor, as president;[18] based on past achievements and honours the player, at the time of his signing, was arguably the most prolific footballer to have competed in the league.

[19] Güiza made his first competitive appearance and league debut for his new team on 8 January 2013, in an opening day away game against Pahang FA: despite a 2–3 defeat, he provided the assists for both of his side's goals.

[21] Three days later, he netted from open play in a home fixture against 2012 Malaysia Cup runners-up ATM FA, with a volleyed lob from the edge of the penalty area in an eventual 2–2 draw.

However, new manager Leonardo Astrada did not have the player in his plans, which led to his release in March 2015[29] despite having a contract running until June;[30] he also cited the poor health of his father as one of the main reasons for his departure.

His arrival drew the ire of fans, due to disparaging remarks he had made about the club a decade ago while playing for local rivals Xerez.

[33] On 26 June 2016, Güiza scored the only goal at Hércules CF in the second leg of the play-off finals (2–0 on aggregate), helping the team return to the second division after six years.

[38] Güiza remained in Sanlúcar de Barrameda for the ensuing seasons, agreeing to new one-year deals in June 2019[39] and May 2020, while his game time and goals decreased.

[47] In the semi-final match against Russia, Güiza netted his second international goal, in a 3–0 win: after receiving a pass from Cesc Fàbregas, he quickly side-flicked it over the goalkeeper.

[49] On 15 October 2008, Güiza came on as a late substitute against Belgium, and soon after assisted David Villa who scored the winning goal in a close 2–1 contest for the 2010 FIFA World Cup qualifiers.

[50] After an article circulated in January 2009 involving details about personal life and behaviour in training, Güiza's international career future was questioned.

[53] On the 28th he came from the bench as the national team trailed hosts South Africa (0–1) in the third-place match, and responded with a spectacular brace in the last two minutes as Spain eventually won the game in extra-time (3–2).

[54] Güiza also played for the Andalusia autonomous team on 27 December 2006, scoring twice in a 3–1 win over a combined Israel–Palestine side at the Estadio de La Cartuja in Seville.