He was called on several occasions by first-team coach Bernd Schuster to train with the seniors and, during the 2006–07 season, played four games for Real Madrid Castilla in Segunda División.

[5] On 4 August 2008, Parejo signed a one-year loan deal with Championship club Queens Park Rangers,[6][7] and made his debut five days later, coming off the bench in a 2–1 win against Barnsley at Loftus Road,[8] going on to total 18 official appearances.

On 17 December, Real Madrid officially recalled the player from his loan effective 1 January 2009, after first-team midfielders Rubén de la Red and Mahamadou Diarra were both out for the campaign with various physical problems.

He appeared little during the season, his first match being the 4–0 La Liga away victory over Sporting de Gijón on 15 February as he replaced Sergio Ramos for the final ten minutes.

[12] Having to compete for a starting berth in central midfield with coach Míchel's son, Adrián – a former teammate in Real Madrid B – he nevertheless contributed solidly during the campaign as they qualified for the second time in their history for the UEFA Europa League.

[14][15][16] On 14 June 2011, Valencia CF signed Parejo for a reported €6 million, with out-of-favour goalkeeper Miguel Ángel Moyá going to Getafe on a year-long loan as part of the deal.

[25] Parejo and Paco Alcácer each scored twice in a 5–1 win away to third-place RC Celta de Vigo on 7 November 2015; his first came just before half-time, through a free kick to put the visitors ahead 2–1.