Daniel Boone School is a historic school building located in the Northern Liberties neighborhood of Philadelphia, Pennsylvania.

It was designed by Irwin T. Catharine and built in 1926–1927.

It is a four-story, eight bay brick building with a two-story center section in the Late Gothic Revival-style.

It features an off-center entrance with arched limestone surround, decorative tile mosaic panels, and a decorative brick and tile cornice.

It was added to the National Register of Historic Places in 1988.