He studied trumpet at Chetham's School of Music and was a member of the National Youth Orchestra at age 13.
After listening to this tape, Rattle hired Harding as his assistant at the City of Birmingham Symphony Orchestra for a year, from 1993 to 1994.
He conducted the 2005 opening night at La Scala, Milan in Idomeneo, as a substitute after the resignation of Riccardo Muti earlier in 2005.
[11] In June 2015, the Orchestre de Paris announced the appointment of Harding as its 9th principal conductor, effective September 2016.
[13] In October 2018, the Swedish Radio Symphony Orchestra announced the extension of Harding's contract as principal conductor through 2023, along with granting him the new title of konstnärlig ledare (artistic leader).
[15] Harding is scheduled to conclude his tenure with the Swedish Radio Symphony Orchestra at the close of the 2024–2025 season.
[20] Harding was appointed a Commander of the Order of the British Empire (CBE) in the 2021 New Year Honours for services to music.