His responsa address topics such as the participation of blind individuals in Torah services, contemporary criteria for determining death, the use of electricity on Shabbat, gene editing, lab-grown meat, and artificial intelligence.
He also allowed for the possibility of chanting from a braille text and suggested that future technologies enabling direct reading from the scroll by blind individuals could meet halakhic requirements.
He maintained that patients declared brain dead can be removed from artificial support, and organ donation with family consent is permissible to save lives.
The responsum on homosexuality, co-authored with Rabbis Dorff and Reisner, highlighted the harm caused by requiring queer Jews to be celibate to comply with rabbinic norms.
The decision, passed by a 13-12 vote, permitted the ordination of LGBTQ rabbis and cantors and allowed same-sex commitment ceremonies, though not equating them with traditional Jewish marriage (kiddushin).
In May 2005, Nevins led a group of Christian leaders on an interfaith trip that included Pope Benedict XVI's first public audience, Holocaust Memorial Day at Titus's Arch in Rome, and a week-long visit to the State of Israel.