As an elder, Parker led a group who separated from that church and formed the Two-Seed-in-the-Spirit Predestinarian Baptists.
Daniel professed conversion before the Nail's Creek Baptist Church in Franklin County, Georgia, and was baptized on January 19, 1802.
In 1803, John & Sarah, Daniel & Patsy, and other Parker family members moved to Dickson County, Tennessee.
He was a strict Predestinarian, but his chief objections in the booklet are based on ecclesiology – for example, "They have violated the right or government of the Church of Christ in forming themselves into a body and acting without of the union."
Several important preachers on the east coast led in the "anti-missions" movement, but Parker was the leader on the frontier, and probably spoke best to the common man.
Therefore, mission activity was not only unbiblical and sinful but, as a practical matter, useless since the "decision" was already made prior to birth.
Parker's two-seeds doctrine identified the serpent as the father of Cain and the originator of a wicked impure seedline.
Parker's teachings coincided with the promotion of the earliest form of Polygenism in the United States by the Kentuckian Charles Caldwell, who believed non-white races could not have descended from Adam.
Daniel Parker's name is almost synonymous with "anti-missions", but he was one of the important frontier preachers in Texas, leading in the organization of about nine churches in the eastern part of the state.