After signing, Ponce de Leon made his professional debut that same season with the State College Spikes of the Low-A New York–Penn League.

[18] He made his major league debut that night as St. Louis's starting pitcher at Great American Ball Park versus the Cincinnati Reds.

[20] In total in 2018 for St. Louis, Ponce de Leon made 11 appearances, with four being starts, posting a 0–2 record with a 2.73 ERA in 33 innings pitched.

[21] Ponce de Leon began the 2019 season in Memphis, but was recalled to St. Louis multiple different times before he was called up for the remainder of the year on September 1.

[27] On April 9, 2022, Ponce de Leon signed a minor league contract with the Seattle Mariners.

[28] He started 16 games for the Triple-A Tacoma Rainiers, struggling to a 5-8 record and 7.95 ERA with 80 strikeouts in 71+1⁄3 innings pitched.

[29] On July 22, 2022, Ponce de Leon signed a minor league contract with the Washington Nationals organization.

On September 9, 2022, Ponce de Leon signed a minor league contract with the Detroit Tigers and assigned to the Toledo Mud Hens.

[32] On April 12, 2023, Ponce de Leon signed a minor league contract with the Chicago White Sox.

[33] He made 8 appearances (7 starts) for the Triple–A Charlotte Knights, but struggled to a 1–4 record and 9.99 ERA with 19 strikeouts in 24+1⁄3 innings pitched.

[34] On June 20, 2023, Ponce de Leon signed with the Diablos Rojos del México of the Mexican League.

In 16 games (9 starts) for the Diablos in 2024, Ponce de Leon compiled a 4–2 record and 4.04 ERA with 64 strikeouts over 42+1⁄3 innings pitched.

[36] Ponce de Leon was born in Anaheim, California, on January 16, 1992, to Ramon and Mary Poncedeleon.