He has appeared in numerous Rob Zombie-directed films, his roles including Morris Green in The Devil's Rejects (2005), The Haunted World of El Superbeasto (2009), and 3 from Hell (2019); Lou Martini in Halloween (2007) and Halloween II (2009); and The Count in The Munsters (2022).

Roebuck has worked with director and producer Don Coscarelli, appearing in Bubba Ho-Tep (2002), John Dies at the End (2012), and Phantasm: Ravager (2016).

Roebuck has provided voice roles in video games, voicing Gary Finkel in Dead Rising 3 and Greez Dritus in both Star Wars Jedi: Fallen Order and Star Wars Jedi: Survivor.

From 1992 to 1995, he played Andy Griffith's assistant lawyer and penultimate private investigator, Cliff Lewis, on the television drama Matlock, and he also had a recurring role as a corrupt officer, Insp.

In 2001, Roebuck played a petty officer in the made-for-TV film A Glimpse of Hell, which explores the 1989 USS Iowa explosion.

Roebuck is a regular player in films by Rob Zombie, starting with The Devil's Rejects (2005), as Morris Green.

As of 2022[update], he is host of Classic with Daniel Roebuck on New Evangelization Television in the New York metropolitan area.

[7] In 2020, he and his wife Tammy founded the non-profit organization A Channel of Peace, which produces faith-based films.