[1] The young artist returned to Antwerp by 1611, where he was enrolled in the Guild of Saint Luke as a pupil of Jan Brueghel the Elder.

[5] The Society's membership consisted principally of citizens from the elite and wealthy middle classes including artists and merchants.

Sources differ regarding his status in the Jesuit order: some claim that he was ordained a priest in 1625,[2] while others argue that he remained a lay brother.

[8] His pupils included Jan Philip van Thielen, Ottmar Elliger and Ignace Raeth and likely also Andries Bosman.

Garland paintings are a special type of still life developed in Antwerp by Seghers's master Jan Brueghel the Elder in collaboration with the Italian cardinal Federico Borromeo at the beginning of the 17th century.

[12] Other artists involved in the early development of the genre included Hendrick van Balen, Andries Daniels, Peter Paul Rubens and Seghers himself.

[12] It was further inspired by the cult of veneration and devotion to Mary prevalent at the Habsburg court (then the rulers over the Southern Netherlands) and in Antwerp generally.

[13] By the second half of the century secular themes such as portraits and mythological subjects also decorated the central part of the many paintings made in this fashion.

[3] Seghers innovated the concept of his teacher Brueghel by including a stone cartouche as the framing elements for the flower garland.

[18] It is possible that Seghers collaborated with Rubens on a garland painting for the Saint Carolus Borromeus church in Antwerp.

[14] Unlike in his later collaborations, Seghers is believed to have added flower garlands to existing paintings by Domenichino during his residence in Rome.

[3] There, the art collector and secretary to the prince Constantijn Huygens praised the paintings in poetry and corresponded numerous times with the artist,[3] writing that one could almost smell the flowers.

[2][3][10] His paintings were usually not sold through traditional contacts such as art dealers, but were instead presented as gifts by the Jesuit order and used for the adornment of churches.

In 1631, for example, Seghers sent a painting of a Crown of Flowers to Marie de' Medici on the occasion of her visit, together with the Infanta Isabella, to the College of St. Ignatius.