In 1722 he married Catharina Elisabeth le Comte in Leiden, and on 21 June that year the couple left for Prussia, where de Superville found employment as a lecturer of anatomy and surgery in Stettin.
Superville soon became a highly influential advisor at the court of Wilhelmina and her husband, Frederick, Margrave of Brandenburg-Bayreuth.
He was admitted to the German imperial academy of sciences in Berlin in 1739 and elected a Fellow of the Royal Society in 1741.
When the university was relocated to Erlangen one year later, Frederick of Brandenburg-Bayreuth appointed himself rector magnificus but kept de Superville on as chancellor.
De Superville was buried at the Vrouwekerk in Leiden (demolished in 1819), which at that time served as Walloon church.