[7][8] Until the age of twelve, she spent her childhood and youth alternately in Australia and in Yorkshire and Cambridgeshire, England, as her father worked in both countries for the BBC Play School.

For her live concert tour in October 2011, titled "Alone and Together", she joined Australian bass player Steve Balbi.

In 2015, Danielle Spencer was a member of Australia's judging panel in the 2015 Eurovision Song Contest.

[13] On 10 July 2020, Spencer released an album with close friend, producer/songwriter Vince Pizzinga, under duo-name 'Lost Luggage'.

She promoted the release on various platforms, including on Channel 7, and The Kyle and Jackie O Show on KIIS 106.5.

She performed the song for the first time on Channel 7 Australia on 3 December as part of the OzHarvest Charity concert, featuring Conrad Sewell, Daryl Braithwaite, Human Nature and many other Australian artists, with a special appearance by Bob Geldof.

Spencer began an on-again, off-again relationship with actor Russell Crowe in 1989 when they co-starred in the film The Crossing which appeared in Australian cinemas in 1990.