Daniele's best-known painting is the Descent from the Cross in the Trinità dei Monti (c. 1545), after drawings by Michelangelo; by an excess of praise this work was at one time grouped with Raphael's Transfiguration and the Last Communion of St. Jerome by Domenichino as the most famous pictures in Rome.

Daniele's two-sided painting of David killing Goliath (restored in 2008) in the Louvre too seems to have been based on Michelangelo's designs; for a long time it was attributed to him.

[2] The 1913 Catholic Encyclopedia gave the following description of Daniele's style as a painter: His work is distinguished by beauty of colouring, clearness, excellent composition, vigorous truth, and curiously strange oppositions of light and shade.

Where he approaches closely to Michelangelo, he is an artist of great importance; where he partakes of the sweetness of Sodoma, he becomes full of mannerisms, and possesses a certain exaggerated prettiness.

A recent author has wisely said: "He exaggerates Michelangelo's peculiarities, treads on the dangerous heights of sublimity, and, not possessing his master's calm manner, is apt to slip down."

His position in present-day criticism is very different to what was given to him a generation ago, and more nearly approaches to a truthful view of his art.Daniele is infamous for having covered over, with vestments and fig-leaves, many of the genitals and backsides in Michelangelo's The Last Judgment fresco in the Sistine Chapel.

This was done because in the original version Blaise had appeared to look at Catherine's naked behind, and because to some observers the position of their bodies suggested sexual intercourse.