Inspired by the African-American bluesmen Son House, Skip James and Mississippi John Hurt, Kalb experimented with acoustic and electronic music.

In 1964 he recorded as Folk Stringers, produced by guitarist and writer Sam Charters, who has written: "It was generally conceded ... that ... Kalb was the most exciting of the new players.".

In 1965, Kalb formed the Blues Project with Steve Katz, Andy Kulberg, Roy Blumenfeld and Tommy Flanders.

They recorded three albums, played frequently at the Cafe Au Go Go and at Murray the K's last "submarine race-watching" spectacular at the RKO 58th Street theater in New York, and made several concert tours, disbanding in 1971.

He was fairly quiet for the next twenty years, but joined Al Kooper for a Blues Project reunion, recorded at the Bottom Line in 1996.

The Danny Kalb Trio recorded I'm Gonna Live the Life I Sing About (Sojourn) in 2008, which received critical acclaim in the blues media.