He is best known as the original drummer and a founding member of the rock band Chicago, a tenure which lasted from February 1967 to May 1990.

[1]: 20–26 In December 1965, after deciding to quit as a professional drummer, he was invited to join Jimmy Ford and the Executives, Dick Clark's road band.

Seraphine cites his influences as Buddy Rich, Tony Williams, Elvin Jones, Grady Tate, Ringo Starr, Mitch Mitchell, and Hal Blaine.

[1]: 47–72 Their producer and manager James William Guercio moved the group to Los Angeles,[1]: 65  where they landed a regular gig at the Whisky a Go Go.

His writing partner was often David "Hawk" Wolinski, the keyboardist for Rufus featuring Chaka Khan although Seraphine has occasionally co-written with other members of the band like Peter Cetera, Robert Lamm and Bill Champlin.

(These Sounds Fall into My Mind)", and later by rapper Pitbull for the hit "I Know You Want Me (Calle Ocho)" from the album "Rebelution".

[1]: 150–151 In 1974, during the peak of the band's career, Seraphine co-founded B'Ginnings, a music venue with capacity of almost 1,000, in the northwest suburbs of Chicago.

[5] After his departure, veteran session drummer Tris Imboden joined the band in time for Twenty 1.

The response from the public was strong enough to persuade Seraphine to continue and write original material with the other band members.

CTA released their first studio album, Full Circle, on August 14, 2007, followed by a tour of the United States.

Former Chicago members like Bill Champlin, Jeff Coffey, Donnie Dacus and Laudir de Oliveira occasionally sat in with the band.