The district reflects the late-19th century and early-20th development of Danville as a tobacco processing center and includes residential, commercial, and industrial buildings reflecting that growth.

It also includes archaeological sites related to early Native American settlements in the area.

Notable buildings include the American Tobacco's Harris Building, the Imperial Tobacco Company Building, Cabell Warehouse, Patton Storage Units (c. 1940), Crowell Motor Company, Municipal Power Station (1912), Riverside Cotton Mill #1 (1886), and a variety of "shotgun" houses and bungalow workers housing.

[3][4] It was listed on the National Register of Historic Places in 1982, with a boundary increase in 2009.

This article about a property in Danville, Virginia on the National Register of Historic Places is a stub.