She is the founder of GSTQ and the CEO and chair of The Garcia Companies overseeing a portfolio of brands in business, entertainment, and food, including Teremana Tequila, Athleticon, and the Project Rock Collection at Under Armour, VOSS, Atom Tickets, Salt & Straw, ZOA Energy, Acorns, and the UFL.

[10][7] She became an associate vice president at Merrill Lynch and started her own wealth management firm, JDM Partners LLC in 2002.

[6][12] In 2008, Garcia executive produced the documentary Theater of War, directed by John Walter and starring Meryl Streep and Kevin Kline.

[3] Garcia then produced the action film Snitch (2013), directed by Ric Roman Waugh and starring Johnson,[20] followed by the reality television series The Hero.

Jumanji: Welcome to the Jungle received positive reviews[36] and grossed $962.1 million worldwide, becoming one of Sony's highest-grossing films of all time.

[44] In 2019, Garcia executive produced The Titan Games, a sports competition series which premiered on NBC and has been renewed for a second season.

[48] Returning to the large screen, Garcia was executive producer for the superhero film based on the DC Comics character of the same name, Shazam!

(2019),[4] The Fast and the Furious spin-off Hobbs & Shaw (2019),[49] and produced Jumanji: The Next Level (2019) which set the record Seven Bucks Productions’ biggest global opening weekend.

[52] As Chairwoman, Garcia led the XFL’s ownership group alongside Dwayne Johnson and Gerry Cardinale's RedBird Capital Partners, which launched on February 18, 2023.

[52] At the end of 2023, the XFL was merged with the Fox Corporation owned USFL to form the United Football League with Garcia retaining partial ownership.

After not releasing any new projects in 2020, Garcia partnered up with Disney for the Disney+ docuseries Behind the Attraction (2021), Disney+ documentary Stuntman (2021), and the blockbuster film Jungle Cruise (2021), based on the classic 1955 Disneyland ride.

In 2008, she founded the Beacon Experience as part of the nationwide I Have a Dream Foundation that encourages at-risk students to continue their education beyond high school.