He made his debut on 10 January 2015 in América's opening game of the Clausura tournament, a 3–2 victory over León at the Estadio Azteca, providing the assist for Oribe Peralta's second goal.

[5] Benedetto was named the best player of the 2014–15 CONCACAF Champions League, and also won the Golden Boot with teammate Oribe Peralta, scoring seven goals in three matches; four in the 6–0 win over Herediano in the second leg of the semi-finals, and a hat-trick in the 5–3 aggregate victory over Montreal Impact in the Finals.

[8] Benedetto scored 30 goals in 34 appearances across his first two Superliga campaigns with Boca but was on target just twice in 15 outings in 2018–19 after returning from the knee and Achilles injuries.

[9] On 5 August 2019, Benedetto signed a four-year deal with Ligue 1 side Olympique de Marseille for a reported fee of €14 million.

[15] On 27 August 2017, Benedetto received his first senior call-up by coach Jorge Sampaoli for Argentina's 2018 World Cup qualifying matches against Uruguay and Venezuela.

[17] Benedetto is a complete striker praised for his eye for goal, his altruism, his sense of collective and his athletic qualities that make him a player appreciated by coaches.