His father worked in the Junta Nacional de Granos in streets of Mendoza and Sarmiento.

His first work in a foreign production was the Bolivian El Día que murió el silencio of 1998, and has recently worked in a number of Spanish films, and also participated as guest in Spanish TV series.

In 2012 he won an International Emmy Award for his role in Televisión por la Inclusión.

In October 1993 he met ex-model and Argentine actress Marisa Mondino with whom he married in 1995 and had two daughters, Lucía (1996-1997) who died in 1997 of hydrocephalus, and Laura.

Finally, after several rumors that linked them together, in 2016 Darío Grandinetti made official his relationship with actress Pastora Vega.