He completed his primary and secondary education in his native town, at the Grupo Escolar Gonçalves Chaves and at the Ginásio Episcopal de Montes Claros.

He is best known for development work in the areas of education, sociology and anthropology and for being, along with his friend and colleague Anísio Teixeira, one of the founders of the University of Brasília in the early 1960s.

During the first mandate of governor Leonel Brizola in Rio de Janeiro (1983–1987), Darcy Ribeiro created, planned and directed the implementation of the "Integrated Centers for Public Instruction" (Centros Integrados de Ensino Público), a visionary and revolutionary pedagogical project of assistance for children, including recreational and cultural activities beyond formal instruction – making concrete the projects envisioned decades earlier by Anísio Teixeira.

Another defeat was in 1994, when he was Brizola's running-mate in the presidential election; Darcy Ribeiro was also chief of staff (Ministro-chefe da Casa Civil) in the cabinet of President João Goulart, vice-governor of Rio de Janeiro from 1983 to 1987 and exercised the mandate of senator from Rio de Janeiro from 1991 until his death.

Darcy Ribeiro's ideas belonged to the evolutionist school of sociology and anthropology, and his main influences were Neoevolutionists Leslie White and Julian Steward, and the Marxist archeologist V. Gordon Childe.