[4] On the first day of competition, 6 July, of the 2021 European Junior Championships at Stadio Olimpico del Nuoto in Rome, Italy, 16-year-old Klepikova advanced to the final of the 100 metre freestyle ranked first with a time of 55.04 seconds.

[21][22] For her performances setting two Russian records and winning two gold medals as a 16-year-old in the senior international competition, Swimming World named her as one of "The Young Talents" for the Championships.

[23] In late November, Klepikova was announced to the roster for Russia at the 2021 World Short Course Championships to be held at Etihad Arena in Abu Dhabi, United Arab Emirates in mid-December.

[2] The first day of competition, 16 December, Kelpikova split a 53.81 for the anchor leg of the 4×100 metre freestyle relay, helping advance it to the final ranked fifth.

[25] In the prelims heats of the 100 metre butterfly on day five, Klepikova ranked 21st overall with a time of 57.86 seconds and did not advance to the semifinals.

[36] Instead, Klepikova focused her efforts on competing in Russia, achieving a personal best time of 54.45 seconds in the 100 metre freestyle at the 2022 Russian Championships in April.

[37] On 26 August, she won the gold medal in the 100 metre butterfly at the Summer Spartakiad with a personal best time of 57.97 seconds.

[3] On the evening of day two, she ranked fourth and qualified for the final of the 100 metre freestyle with a time of 55.01 seconds in the semifinals of the event.

[44] For her first event of the evening session, the 50 metre butterfly semifinals, she qualified for the final with an overall rank of sixth and a time of 26.72 seconds.