The online e-zine, Post Apocalyptic Dispatch, continues to provide short articles that support game play for both gamemasters and players alike.

In specific, its use of real-life deformities and genetic diseases to portray character defects, as well as issues like slavery, racism, and drug use give it a grittier quality than most post-apocalyptic RPGs, which often have a fantastic or "comic book" feel that requires a broader willingness to suspend disbelief.

There is a strong focus on regions that once constituted the Midwest and Western United States; numerous modules published for the game are nominally set in "desert" or "wasteland" areas.

More specific locations include the desert trade town of Tucumcari, the sunken city of Bakersfield and its strange subterranean monsters, the overgrown ruins of Los Angeles, a San Francisco overrun by anti-technology zealots, and a decadent society thriving in the futuristic domed cities of the Midwest.

Numerous adventures written for Darwin's World either briefly feature, reference, or center around real-life places and events.