The theater, which opened in 1998, is housed in the four-story Union Square Savings Bank building, which was designed by Henry Bacon and built between 1905 and 1907.

[1] The original structure, a New York City landmark, houses a theater that can accommodate 300 seated or 499 standing patrons.

The initial plans published in the Real Estate Record in October 1905 depicted a 25-by-100-foot (7.6 by 30.5 m), two-story marble building costing $100,000.

[12] In 1993, the House of Blues concert-venue company bought the bank and its annex at 103 East 15th Street for a combined $2.06 million.

[14] However, that June, the House of Blues withdrew its application for a liquor license, which would have enabled the restaurant to contain a bar.

[15] Manhattan Community Board 5, which covers Union Square, expressed concerns about the effects of a concert venue in the neighborhood, so the House of Blues agreed to delay construction in exchange for postponement of a public hearing.

[16] In 1996, the building was acquired by Daryl Roth,[17] who had devised plans to turn the bank into an off-Broadway venue.

The renovations required moving the box office around, but upon the completion of work, the audience was able to enter through the front doors on Union Square East.

[5] The Daryl Roth Theatre building is located above a foundation of brick, with a concrete base, and contains a facade with white granite cladding.

[24] Fuerza Bruta was produced at the Daryl Roth Theatre from 2006 to 2016,[25] while Striking 12 ran from November to December 2006.