[4] Sabara began acting during the mid-1990s, appearing on episodes of Murphy Brown, Life's Work, Friends and Will and Grace before being cast as Juni Cortez in the Spy Kids series of family films, which became popular among pre-teen audiences.

He has appeared in episodes of the television series Weeds, House, Dr. Vegas, and was one of the judges on America's Most Talented Kid.

Sabara also voiced the main character, Hero Boy, in the 2004 animated version of The Polar Express.

He then played a young Jewish boy trying to have a nice Bar Mitzvah in Keeping Up with the Steins (formerly known as Lucky 13), which received a limited release on May 12, 2006.

He next appeared in the films Her Best Movie and the interactive DVD Choose Your Own Adventure, played Ben on The Last Chance Detectives radio dramas by Adventures in Odyssey and Focus on the Family,[5] and also appeared as school bully Wesley Rhoades in Rob Zombie's Halloween.

He played Kyle, a misanthropic teenager in World's Greatest Dad, with Robin Williams, and Peter Cratchit in the 2009 film adaptation of A Christmas Carol.

In 2014 he starred alongside Chloë Grace Moretz in the off-Broadway play The Library directed by Steven Soderbergh.