Daryl Dean Spencer (July 13, 1928 – January 2, 2017) was an American professional baseball player and infielder who played shortstop, second base and third base in Major League Baseball between 1952 and 1963 for the New York / San Francisco Giants, St. Louis Cardinals, Los Angeles Dodgers and Cincinnati Reds.

On April 15, 1958, he hit the first home run in San Francisco Giants' history in an 8–0 victory over the Dodgers.

He signed with the Giants in 1949 and, in his first full MLB season, 1953, he started a combined 108 games at three infield positions, hitting 20 home runs, a career high.

His Opening Day 1958 homer, hit at San Francisco's Seals Stadium against the Dodgers' Don Drysdale, a future Baseball Hall of Famer, came in the fourth inning; the solo shot made the score 3–0 at the time.

[1] The contest was the first-ever in California for the Giants and Dodgers after each team had moved from New York City during the offseason.

This incident would be similar to the Sadaharu Oh single season home run incident many years later, with foreigners Randy Bass, Tuffy Rhodes, and Alex Cabrera, where they would get intentionally walked to prevent them from breaking Oh's single season home run record of 55.