Mayer has at various times told different, and sometimes conflicting, stories as to the inspiration for the song, ranging from MTV's Real World (in a Sirius Morning Mash Up Show interview in May 2007) to an unnamed ex-girlfriend.

In 2010, on VH1's Storytellers, Mayer stated that he wrote the song about an ex-girlfriend who had trust issues because of her absent father, which led to the decline and eventual split of their relationship.

Mayer had been resistant on releasing the song as a single,[3] and was still skeptical despite the Grammy win, which he mentioned in his speech upon receiving the award.

[4] On several occasions, Mayer had pushed to release the songs "Come Back to Bed" and "Something's Missing" as singles, as they were more the kind of music he was leaning towards making.

"Come Back to Bed" and "Home Life" are the same live versions that appear on Mayer's as/is volumes released in 2004 "Daughters" was played at the end of the 7th Heaven episode "The Fine Art of Parenting".