There, he became involved with the student-run TV station, Plattsburgh State Television (PSTV), working both on production behind the scenes and on the air as well.

[6] In 2006, Annable was cast as Justin Walker on the ABC drama series Brothers & Sisters alongside Calista Flockhart, Rachel Griffiths, and Sally Field, which was picked up for a full season by the network.

[10] In January 2012, Annable was confirmed to star as the male protagonist on the ABC supernatural drama series 666 Park Avenue alongside Rachael Taylor, Vanessa Williams and Robert Buckley, which was picked up for a first season of 13 episodes in May.

In 2014, Annable starred on the Fox series Red Band Society, where he played the role of pediatric oncologist and surgeon Dr. Adam McAndrew.

[19] On April 5, 2016, it was announced that Annable joined the WWE Studio action film Armed Response alongside Wesley Snipes and Anne Heche.

He also starred as author Joe McGinniss in Jeffrey MacDonald true crime murder movie Final Vision on Investigation Discovery.

[21] On August 3, 2017, Annable was cast as Lee Dutton, a cowboy who serves as his father's (Kevin Costner) right-hand man in running the ranch, in the pilot episode of Paramount Network's period drama Yellowstone.

[22] He starred as Billy opposite his real life wife Odette Annable in a Freeform holiday movie No Sleep 'Til Christmas.