Bush graduated from Conestoga High School in Berwyn, Pennsylvania[1] and played college baseball at Wake Forest University where he was a double major in psychology and sociology.

[2][3][4] On August 11, 2010, in a game against the Arizona Diamondbacks, Bush became the third player in Major League history to allow four straight home runs (Paul Foytack and Chase Wright were the others).

Bush was touched for consecutive solo blasts by Adam LaRoche, Miguel Montero, Mark Reynolds and Stephen Drew.

[10] Bush started the 2013 season with the Triple-A Buffalo Bisons, but the Blue Jays brought him up on April 6 when Jeremy Jeffress was designated for assignment.

Lyle Overbay, the man Bush was traded for, led off the eighth inning with a triple to end the bid.

In an April 23, 2009 game against the Philadelphia Phillies, he once again took the no-hit bid 7+1⁄3 innings before giving up a home run to Matt Stairs.