David Leon Holmes (January 7, 1924 – August 25, 1999) was an American football player, coach, and college athletics administrator.
Holmes then went on to the University of Hawaii (1968–1973), where he still holds the record for highest career winning percentage (.718).
Holmes was a graduate of Tonasket High School and Whitworth College in Spokane, Washington.
Prior to his tenure at Eastern Washington, he was the head coach at North Central High School, where he compiled a 35–28–4 record.
Holmes died on August 25, 1999, at the age of 75 of an apparent heart attack while fly fishing in Northern Idaho.