Born in New Jersey and raised in St. Louis, Holmes's family includes parents Charles and Mary Lou and two older brothers, Dan and Steve.
He went on to host several MTV shows, including 120 Minutes, Video Clichés, a Real World reunion special, and the popular Say What?
[1] On September 23, 2010, Holmes contributed a video to the "It Gets Better" project,[2] spearheaded by advice columnist and gay rights activist Dan Savage.
Since 2003, Holmes has co-hosted the live comedy game show The Friday Forty with The Walking Dead executive producer Scott M. Gimple.
On 28 June 28 2016, Penguin Random House's Crown Archetype imprint published Holmes' nonfiction book Party of One: A Memoir in 21 Songs.
The memoir chronicles Holmes's experiences coming to self-acceptance during adolescence and early adulthood, with popular music as a guide and backdrop, from the 1980s through the present day.