[2]: 84 He described his break into the industry as "a genuine lucky, fluky" one; initially temping on the oil and future trading floor at 399 Park Avenue, he declined a job offer given to him at the building.
[2]: 83 A week after declining, he heard a recorded message from production members of Beavis and Butt-head regarding his roommate, Nate, from whom he was subletting at his apartment.
[2]: 84 For his work for Celebrity Deathmatch, Hughes was quoted on how his coworkers had to assemble a weekly series in the five months between its appearance in Cartoon Sushi and premiere in May 1998.
[2]: 84 [4]: 34 After the studio folded, Hughes started working for Nickelodeon, creating station IDs and brand elements for the network's spinoff channel, Nicktoons.
[7] He later created his own series, Off the Air, which premiered on the network, unannounced, on New Year's Day 2011 at 4 a.m.[a] He took inspiration from the experimental programming he watched while in New York City.
"[2]: 85 Hughes stated that he incorporates clips "with some kind of truth or integrity to them", and that viral videos as well as obscure content are put into episodes.
[9] For the 2014 San Diego Comic-Con, he was the creator of an animated short presented in a planetarium-like structure, entitled the Meatwad Full Dome Experience.