[1] He made his MLB debut for the franchise on September 18, 1960, nine days before his 25th birthday,[1] pitching two innings, giving up an earned run, and striking out one in a 9–2 loss against the Cleveland Indians.

[5] In 1962, he posted an 11–4 win–loss record and led American League pitchers with a .733 winning percentage, and went 12–15 with a 3.78 earned run average (ERA) the following year.

[1] He was traded along with Jerry Lumpe and Ed Rakow from the Athletics to the Detroit Tigers for Rocky Colavito, Bob Anderson and $50,000 on November 18, 1963.

[6] Wickersham enjoyed his most productive season for Detroit in 1964, when he went 19–12 with a 3.44 ERA and posted career-numbers in strikeouts (164), starts (36), complete games (11), appearances (40), and innings pitched (254.0).

Over his 10-season MLB career, Wickersham posted a 68–57 record with 638 strikeouts and a 3.66 ERA in 1,123 innings, including 29 complete games, five shutouts and 18 saves.

[1] Notably, he was one of three players (along with fellow pitchers Aurelio Monteagudo and Moe Drabowsky) to play for both Kansas City-based major league teams, the Athletics and Royals.