[5] Arquette rose to recognition with roles in films such as Buffy the Vampire Slayer (1992), Wild Bill (1995), Never Been Kissed (1999), See Spot Run (2001), and Eight Legged Freaks (2002).

His television credits include CBS' Double Rush (1995), ABC's In Case of Emergency (2007), and Disney Channel's animated series Jake and the Never Land Pirates (2011–2016).

[6][7][8] He is the youngest child of Brenda "Mardi" Olivia (née Nowak), an actress, burlesque dancer, poet, theater operator, activist, acting-teacher, and therapist, and Lewis Arquette, a puppeteer and actor.

Arquette's mother was Jewish (from a family that emigrated from Poland)[12][13][14][15] while his father was a convert from Roman Catholicism to Islam; through him, David is distantly related to explorer Meriwether Lewis.

The couple married in 1999; together, they appeared in a 2003 advertisement for Coke and formed the production company Coquette (both a portmanteau of their last names and a word meaning a flirty woman),[26][27] which has produced a number of films and television series, including Daisy Does America, Dirt and Cougar Town.

Arquette, a well known horror fan, made his directorial debut with 2007's The Tripper and has signed on to direct Glutton, a 3D psychological thriller.

On October 7, 2013, Arquette's new show Dream School, in which he plays a mentor to high risk kids in L.A., premiered on the Sundance Channel.

In May 2020, it was confirmed that Arquette would be reprising his role as Dewey Riley for the fifth Scream film, which was directed by Matt Bettinelli-Olpin and Tyler Gillett.

He made his first appearance on the April 12, 2000, episode of Thunder, sitting in the crowd before leaping into the ring to take part in a worked confrontation with Eric Bischoff and his New Blood stable.

[3] Afterwards, he formed an alliance with Chris Kanyon and then reigning WCW World Heavyweight Champion Diamond Dallas Page, and with their help, he defeated Bischoff in a singles match on the April 24 episode of Nitro.

[40] On the following episode of Thunder, Arquette teamed with Page in a match against Bischoff and Jeff Jarrett, with the stipulation that whichever man got the pin would take the championship.

In another portion of the show, Arquette was seen backstage trembling in fear and attempting to "give back" the championship belt.

[43] After Slamboree, Arquette cut a promo on the May 8 episode of Nitro, explaining that his entire friendship with Page and title run was a "swerve".

[44] Arquette made one final appearance with WCW at the New Blood Rising pay-per-view on August 13, when he interfered in a match between Buff Bagwell and Kanyon.

Arquette was against the idea of becoming the WCW World Heavyweight Champion, believing that fans like himself would detest a non-wrestler winning the title.

On the December 13, 2010, episode of Raw, Arquette made his WWE debut by teaming with Alex Riley in a handicap match against Randy Orton, which they lost.

[48][49] In 2018, during an interview on The Wendy Williams Show, Arquette said that, in the years following his controversial WCW title win, he had been trolled on the Internet and that he wanted people to have respect for his name in professional wrestling.

On November 16, 2018, Arquette wrestled Nick Gage in a deathmatch at Joey Janela's LA Confidential event.

Neither of them recognized him at first, however they eventually recalled his WCW World Heavyweight Championship reign but still refused to let him compete, instead, giving him a double Superkick.

In June 2012, while in Israel to film an episode of the travel show Trippin, Arquette belatedly celebrated his Bar Mitzvah at the Western Wall.