[1] His younger brother John Campbell (1787 or 1788 – by 29 January 1867) served as treasurer of the United States from 1829 to 1839, and would be buried at Morristown, Shelby County, Indiana.

Another younger brother, Edward McDonald Campbell (1781–1833), represented Lee, Russell, Scott, Tazewell, and Washington Counties in the Virginia Constitutional Convention of 1829–1830, and Edward's son John Arthur Campbell represented the area at the Virginia Secession Convention of 1861 and also served as a Confederate infantry captain and circuit judge.

He served in the U.S. Army during the War of 1812 and was Captain in the Virginia militia and aide-de-Camp to Governor James Barbour during that conflict.

He called a special session of the General Assembly that helped Virginia weather the financial Panic of 1837.

Although Virginia's state slave schedules for that county in 1850 also show a David Campbell as an enslaver, such records are unavailable online.