Guiding Light alum Irizarry joined the cast of All My Children from November 27, 1997, to March 2, 1998, for what was initially meant to be a short term role.

Following nine years in the role, Irizarry exited the series on November 28, 2006, with executive producer Julie Hanan Carruthers citing financial and storyline reasons.

David ends up leaving Pine Valley for a short time, but returns less than a year later in an attempt to woo Liza Colby, with whom he has grown infatuated.

David remains a common enemy of the Martin family throughout the next several years, constantly at war with Jake and his father, Joe.

When Bianca suffers heart problems as the result of her eating disorder (anorexia nervosa) it is David who treats her and ultimately helps her survive.

Shortly after his relationship with Erica ends, David pours Libidozone, a drug he created and uses to arouse sexual desires, into a punch bowl at a party aboard a yacht.

Babe is the product of a one-night stand with Krystal Carey when he was a student in medical school, and he was completely unaware that the liaison resulted in a child.

His crimes concerning the baby switch also cost him his medical license for quite some time, and he is forced to perform community service at Pine Valley Hospital as a janitor.

David left Pine Valley in the fall of 2006 after making a video exposing many of his enemies' secrets and leaving it for interested parties to see.

The killer, also known as "The Satin Slayer", is later revealed to be Alexander Cambias Sr. David returns to Pine Valley in the fall of 2008.

David makes a contract with Amanda which lets her move out his house and share custody of their son if she agrees to have another baby with him through artificial insemination.

In November 2009, David also finds out that Trevor is not his son, but he doesn't tell Amanda and instead lets her believe he is dying from a rare blood disease and has six months to live.

Amanda finds out in January 2010 that Jake is Trevor's biological father, getting rid of David from their lives permanently.

Meanwhile, Ryan Lavery discovers Greenlee's medical records on David's computer, who claims he was using them for research into Amanda Dillon's pregnancy.

Greenlee asks David to marry her, hoping that when she walks down the aisle at her wedding, everyone will be surprised, and that Ryan will be hurt.

In retaliation, Greenlee sets up Erica for siphoning money from the Miranda Center to her Fusion Glam line with David's help.

David also sabotages Erica's plane believing it would delay her just long enough for Greenlee to step in as leader with the scandal being out.

David requests a last dinner with her, during which he tells Greenlee he has framed her for the Miranda Center scandal and Erica's plane crash.

On September 13, 2010, the medical examiner tells Greenlee that David's autopsy reveals he didn't die of trauma or from a fight, but was poisoned with the drug Digitalis.

He takes the stand and says that he faked his own death to keep Ryan Lavery from Greenlee, and that he managed the deception by bribing the medical examiner.

Marissa slaps and verbally attacks him for leaving her, while Kendall explodes and blames him for setting things in motion that led to Zach's death.

On November 29, 2010, David escapes the prison transport and attacks Ryan at his house with the intent to kill him and kidnap Greenlee.

Later, Kendall, devastated to the point of irrationality by Zach's death, impulsively tries to smother David at the hospital, but is stopped by Griffin Castillo.

Upon discovering David's awakening, Marissa offers to be his defense attorney and hopefully get him to turn over a new leaf, but assures her father that if he doesn't do exactly as she says, she will see to it personally that he is thrown in prison.

Upon realizing that his selfish refusal to let Greenlee go resulted in the needless suffering of several people, including Zach's death and his own bullet wound, David agrees to sign the papers.

At that moment, Marissa, having been informed of the situation by Greenlee, arrives and threatens to turn David in unless he reveals Emma's whereabouts.

On March 3, 2011, David approaches Ryan and Greenlee and offers to help them track down Annie and Emma, and they reluctantly accept.

While David is laying low he has a series of flings with Liza Colby, as she has also recently been publicly humiliated and shunned as it was revealed that she slept with her daughter's boyfriend.

Jake and Griffin realized that David would require emergency surgery to repair the internal bleeding.

In the final days of the ABC version of All My Children, David is involved with Cara Castillo, who is carrying his child.