David Howard Harrison (June 1, 1843 – September 8, 1905) was a politician, farmer and physician.

On August 27, 1886, Harrison was appointed Minister of Agriculture, Statistics and Health, and was touted as a possible successor to Norquay.

Norquay was forced to resign in early December 1887, after a financial crisis involving railway transfers cost him the support of his ministers.

Harrison became Premier on December 26, 1887, and attempted to form an administration from the remnants of Norquay's alliance.

He was unable to win the support of a clear majority of MLAs, and lost a vital by-election on January 12, 1888.