Born in Barcelona, Catalonia, López finished his youth career with local RCD Espanyol, and made his senior debut with the reserves in the 2008–09 season, in Tercera División.

López returned to Espanyol in June 2010, and made his main squad – and La Liga – debut on 26 September, coming on as a late substitute in a 1–0 home win against CA Osasuna.

[8] He made his Serie A debut on 21 September, playing the full 90 minutes and being booked in a 1–0 defeat at Udinese Calcio.

[10] López scored his first competitive goal for the Italians (from 39 appearances) on 7 May 2015, putting his team ahead in an eventual 1–1 home draw against FC Dnipro Dnipropetrovsk in the semi-finals of the UEFA Europa League.

[12] During most of his second spell he was utilised by manager Quique Sánchez Flores as a central defender[13][14] and, from that position, he scored in a 4–1 away loss to FC Barcelona in the Derbi barceloní on 18 December.

[16] He scored a top-flight best of four goals in the 2019–20 campaign, but his team were relegated;[17][18] this started with the opener on 4 January in a 2–2 draw with Barcelona at the RCDE Stadium.