After leading the team in batting average in his senior year, the Chicago Cubs selected Macias in the 19th round of the 2008 MLB draft.
[1] Macias made his professional debut with the Low-A Boise Hawks, hitting .228/.316/.288 in 54 games.
In 2009, Macias split the year between the Single-A Peoria Chiefs and Triple-A Iowa Cubs, hitting a cumulative .241/.313/.289 with 32 RBI and his first professional home run in 114 combined games.
The following season, Macias played for the High-A Daytona Cubs and the Double-A Tennessee Smokies, posting a slash of .224/.277/.283 with 2 home runs and 34 RBI in 106 games between the two teams.
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