Sengeh was offered a scholarship to study in Norway, and joined the UWC Red Cross Nordic College in 2004.

[6][7] During his time at Harvard University, he was cofounder of Lebone Solutions, a start-up that developed inexpensive batteries from microbial fuel cells.

[12][13] He used MRI to map amputee's limbs, then assessed where artificial materials could create pressure points, and used 3D printing to generate new sockets.

[23] The "A De Mek Am" Innovate Salone program supports teams from secondary schools to develop solutions to local problems.

[5] He supported Kelvin Doe, a thirteen year old inventor who had never left a ten-mile radius of his house in Sierra Leone, to join the MIT Visiting Practitioner's Program.

[31] He worked with IBM Research in Nairobi, as well as in their newest lab in Johannesburg, designing and developing healthcare technologies in Africa.

[33] He partnered with Port Loko Health Management Team to design a web-based tool that allows districts to monitor Ebola.

[40] On 10 July 2023, Sengeh was appointed as the Chief Minister of Sierra Leone by President Julius Maada Bio.