On 13 June 2018 he was named Minister of Internally Displaced Persons from the Occupied Territories, Accommodation and Refugees in the cabinet of Mamuka Bakhtadze.

[4] After Ivanishvili's Georgian Dream coalition won the October 2012 parliamentary election and subsequently formed the new government, Sergeenko was made Minister of Health, Labor, and Social Affairs in the cabinets of Ivanishvili and of his protégé and successor, Irakli Garibashvili.

[6] As the Georgian government's support to post-revolutionary Ukraine amid a brewing confrontation with Russia was reserved, Sergeenko was the only Georgian minister to have visited Kyiv in August 2014; he then oversaw Georgia's humanitarian aid, worth of about GEL 1 million (US$570,000), to Ukraine in September 2014.

[7][8] Sergeenko was also behind the controversial law adopted in August 2014, tightening the regulation of prescription drugs.

[9] He also suggested, in May 2013, that Georgia might consider decriminalization of marijuana as part of the strategy to tackle on illicit drug-trafficking channels.