He has toured extensively throughout the United States with CMSLC and hosted and performed in several nationally televised broadcasts on PBS’s Live from Lincoln Center.

David Shifrin has been instrumental in broadening the repertoire for clarinet and orchestra by commissioning and championing the works of 20th- and 21st-century American composers including John Adams, Joan Tower, Stephen Albert, Bruce Adolphe, Ezra Laderman, Lalo Schifrin, David Schiff, John Corigliano, Bright Sheng and Ellen Taaffe Zwilich.

[5] Shifrin is also the recipient of a Solo Recitalists' Fellowship from the National Endowment for the Arts, an Avery Fisher Career Grant and the 2016 Concert Artists Guild Virtuoso Award.

His most recent recordings include the Beethoven, Bruch and Brahms Clarinet Trios with cellist David Finckel and pianist Wu Han (pianist) on the ArtistLed label; and a recording for Delos of works by Carl Nielsen, which includes the first commercial recording of the Nielsen Clarinet Concerto arranged for chamber orchestra, as well as Nielsen's Wind Quintet and various short works either written or arranged for clarinet and piano.

[8] Another Delos release from 2019 features Shifrin with the Dover and Harlem Quartets in music by Duke Ellington (arranged by David Schiff), Valerie Coleman and Chris Rogerson.