He played college football for the Syracuse Orange and was selected by the Giants in the sixth round of the 2003 NFL draft.

Tyree is best known for the Helmet Catch, a late-game reception in Super Bowl XLII that helped New York secure one of the greatest sports upsets of all time.

Tyree earned Pro Bowl and first-team All-Pro honors in 2005 as a special teams player, but was utilized as a backup for most of his career.

Nevertheless, Tyree earned recognition during the Giants' last drive in Super Bowl XLII when he caught a third down pass by pressing the ball against his helmet.

Following the conclusion of his playing career, Tyree rejoined the Giants as their director of player development, holding the position from 2014 to 2017.

In 2008, Tyree was placed on injured reserve for a knee injury suffered during training camp after being on the physically-unable-to-perform list most of the season.

[7] Later, on a third-and-five with 1:15 remaining and trailing 14–10, Manning eluded a sack and threw 32 yards downfield toward Tyree.

[11] Tyree dedicated this catch, the last one he ever made in an NFL game, to his mother, Thelma, who died of a heart attack that year.

[15] Tyree battled with alcohol addiction beginning in middle school, and in March 2004, he was arrested by the Fort Lee Police Department[16] for possession of marijuana.

[21] Tyree said in an interview that the passage of the Marriage Equality Act would "be the beginning of our country sliding toward...anarchy".