David Zeisberger (April 11, 1721 – November 17, 1808) was a Moravian clergyman and missionary among the Native American tribes who resided in the Thirteen Colonies.

He established communities of Munsee (Lenape) converts to Christianity in the valley of the Muskingum River in Ohio; and for a time, near modern-day Amherstburg, Ontario.

Zeisberger was born in Zauchtenthal, Moravia (present day Suchdol nad Odrou in the Czech Republic) and moved with his family to the newly established Moravian Christian community of Herrnhut, on the estate of Count Nicolaus Ludwig von Zinzendorf in the German Electorate of Saxony in 1727.

However, when his family migrated to the newly established colony of Georgia, Zeisberger remained in Europe to complete his education.

At the time, the United Brethren had begun a settlement, merely for the purpose of preaching the gospel to the Creek Indians.