It has four gallery spaces in New York City and one each in Los Angeles, London, Hong Kong, and Paris.

[1] The Zwirner Gallery opened in 1993 on the ground floor of 43 Greene Street in SoHo in New York City[2] with a one-man show of the Austrian sculptor Franz West.

[6] In September 2017 it opened an Upper East Side space in a 1907 townhouse off Madison Avenue, redesigned by Selldorf.

[1][9] In 2019 the gallery opened an 800 m2 (8,600 sq ft) outpost in the Marais district of Paris, its first in continental Europe.

[10][11] In 2023 it opened a 1,300 m2 (15,000 sq ft) branch in the Melrose Hill neighborhood of Los Angeles, California.