She hosted Channel 4's Streetmate (1998–2001, 2016), The Million Pound Drop (2010–2015), Five Minutes to a Fortune (2013), and The Jump (2014–2017), as well as ITV's The Biggest Loser (2011–2012), Long Lost Family (2011–present), and This Time Next Year (2016–2019).

Since 2020, she has been a judge on the ITV musical competition show The Masked Singer, McCall was appointed Member of the Order of the British Empire (MBE) in the 2023 Birthday Honours for services to broadcasting.

[13][14] Dissatisfied with her lack of success in the music industry, McCall gave up singing and took a job at Models 1 on the men's desk as a booker.

[20][21] In 1998, McCall hosted the cult dating show Streetmate, in which she toured the country meeting single people and matching them up.

It originally ran on Channel 4 from 1998 to 2001[22][23] McCall was chosen as the presenter of the inaugural series of Big Brother,[24] in which ten housemates entered a sealed house for up to nine weeks and their every move was filmed and then broadcast as a daily highlights television show.

McCall hosted the weekly live eviction show, where one contestant would be removed from the house, until the last housemate became the winner.

[25] McCall's performance on the final night of the sixth series in 2005 attracted press attention and some complaints for her treatment of housemate Makosi Musambasi.

[34] In between the final celebrity and regular editions of Big Brother on Channel 4, McCall began presenting a new game show, The Million Pound Drop.

[38][39] From 2012 to 2016, McCall co-hosted charity telethon Stand Up to Cancer with Alan Carr, Christian Jessen and Adam Hills.

[40] From January 2014 to March 2017, McCall presented reality competition The Jump which was broadcast live from Innsbruck and Kühtai in Austria.

Organised on an alternating comedy/sport theme and televised live in March, Red Nose Day has been co-hosted by McCall since 2005.

Receiving scathing reviews and with viewing figures falling to below half of the six million watching The Bill on ITV at the same time, the show was cancelled in April for not reaching expectations with McCall herself saying that the programme was "the worst mistake of her life".

[60] In 2005, McCall made a cameo appearance in the Doctor Who episode "Bad Wolf" as the voice of Davinadroid, a robot who controlled a future version of the Big Brother house.

[63] The show aims to empower people to embrace midlife, by sharing stories of growth, rediscovery and creating a sense of renewal.

[64][65] In 2001, McCall appeared with Ed Byrne, Tristan Gemmill and Tameka Empson as the title character in Sam's Game, a Friends-style sitcom and was widely panned by the critics, it only aired once.

[citation needed] In August 2014, McCall was one of 200 public figures who were signatories to a letter to The Guardian expressing their hope that Scotland would vote to remain part of the United Kingdom in September's referendum on that issue.

[70][71][72] McCall was appointed Member of the Order of the British Empire (MBE) in the 2023 Birthday Honours for services to broadcasting.

[81] In June 2000, McCall married her second husband Matthew Robertson, presenter of Pet Rescue, at Eastnor Castle, Herefordshire.

With the help of historians Jean-Marc Berliere and Simon Kitson, McCall learned that she is the great-granddaughter of Prefect of Police Célestin Hennion (1862–1915), and the great-great-great-granddaughter, on her father's side, of James Thomas Bedborough (1787–1860), a stonemason, councillor, Mayor, property developer and entrepreneur, who worked on Windsor Castle and Upton Park in Slough.

Bedborough was said to be an illegitimate son of George IV according to a story told by McCall's grandmother, but this was neither proved nor disproved on the show.

[88] In November 2024, McCall announced that she had been diagnosed with a colloid cyst, a rare type of benign brain tumour, and would undergo neurosurgery.

[89][90] McCall later stated that she was struggling with her short-term memory following the surgery [91] but was now at home recovering, she said: “I’m on the mend, I’m resting, I’m sleeping loads, I feel really good.