Davis–Beirut reaction

The oxygen and its hydrogens then leave as a molecule of water (4), creating a double bond with the previously negatively charged nitrogen atom.

[1][6] In 2014, Thiazolo-, Thiazino-, and Thiazipino-2H-indazoles were synthesized utilizing o-nitrobenzaldehydes or o-nitrobenzyl bromides and S-trityl-protected primary aminothiol alkanes with a base, such as KOH, in alcohol.

[1] Creating Thiazolo-, Thiazino-, and Thiazipino-2H-indazoles is beneficial since they are generally more stable than the oxo-2H-indazoles formed without the S-trityl-protected group, and they can easily be oxidized to sulfones.

[1] Creating 2H-indazoles via the Davis–Beirut reaction can also help in producing 1H-indazoles, naturally occurring and synthetically made molecules with known pharmaceutical uses such as anti-inflammatories and anti-cancer drugs.

[4][6][10] Due to the recentness of the discovery of this reaction, though, most research is primarily headed by Haddadin, Kurth, or both, therefore causing a currently limited scope.