Guggenheim directed the episodes "Deep Water",[9] "Reconnoitering the Rim",[10] "Plague"[11] and "Sold Under Sin".

The film, released in 2006, featured former U.S. Vice President Al Gore and his international slideshow on global warming.

Then-candidate Barack Obama's biographical film, which aired during the Democratic National Convention in August 2008, was directed by Guggenheim.

Their infomercial, which was broadcast two months later, on October 29, 2008, was "executed with high standards of cinematography", according to The New York Times.

In 2008, he released It Might Get Loud, a documentary that glimpses into the lives of guitarists Jimmy Page, The Edge, and Jack White.

Guggenheim's 2010 documentary Waiting for "Superman", a film about the failures of American public education sparked controversy and debate.

[16] In 2013, he directed The Dream is Now, a 30-minute documentary about four undocumented students in the United States as they deal with the U.S. immigration system.