Dayton's Bluff is a neighborhood located on the east side of the Mississippi River in the southeast part of the city of Saint Paul, Minnesota which has a large residential district on the plateau extending backward from its top.

Indian Mounds Park preserves some of the burial sites of an early group that came to the area more than a thousand years ago.

The area was named for Lyman Dayton, land and railroad speculator who built a home on the Bluff in the 1850s.

Feed, flour, and lumber mills were built in the area in the 1850s and used Phalen Creek as a source of water power.

After a railroad was built north of East 7th Street in the late 1860s, more industries, including Hamm's Brewery, grew along its corridor.

He came to Minnesota in 1849, settled in St. Paul, invested largely in real estate, and was the president of the Lake Superior and Mississippi Railroad.