De-Loused in the Comatorium is the debut studio album by American progressive rock band The Mars Volta, released on June 24, 2003, on Gold Standard Laboratories and Universal Records.

Based on a short story written by lead singer Cedric Bixler-Zavala and sound manipulation artist Jeremy Ward, the concept album is an hour-long tale of Cerpin Taxt, a man who enters a week-long coma after overdosing on a mixture of morphine and rat poison.

Following the departure of Eva Gardner who had appeared on the band's early demos and EP, Red Hot Chili Peppers bassist Flea performed on De-Loused.

The music contained in De-Loused is distinguished by its enigmatic lyrics, Latin and jazz rhythms, and Rodríguez-López's frenetic guitar riffs, which are often strongly dissonant.

"[19] Playlouder gave it a score of four stars out of five and said, "There are moments of prog rock, jazz fusion and freakydelia in this rush of ideas and if that sounds awful then don't be put off.

[6] All lyrics are written by Cedric Bixler-Zavala with the help of Jeremy Ward; all music is composed by Omar Rodríguez-López, except where notedThe following people contributed to De-Loused in the Comatorium: ^ Shipments figures based on certification alone.